Publications

Mulla S, Ludlam AR, Elragig A, Slack C, Balklava Z, Stich M, Cheong A (2023). A biphasic model of lifespan in nematode Caenorhabditis elegans worm. Royal Society Open Science 10 (2), 220991.

Laskovs M, Partridge L, Slack C (2022). Molecular inhibition of RAS signalling to target ageing and age-related health Disease Models & Mechanisms 15 (10), dmm049627.

Chen Z, Cordero J, Alqarni AM, Slack C, Zeidler MP, Bellantuono I (2022). Zoledronate extends health span and survival via the mevalonate pathway in a FOXO-dependent manner. The Journals of Gerontology: Series A 77 (8), 1494-1502.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G (2019). To help aging populations, classify organismal senescence. Science 366(6465):576-578.

Wiseman DN, Otchere A, Patel JH, Uddin R, Pollock NL, Routledge SJ, Rothnie AJ, Slack C, Poyner DR, Bill RM, Goddard AD. (2019). Expression and purification of recombinant G protein-coupled receptors: A review. Protein Expression and Purification 31: 105524.

Slack, C and Tullet, J (2019). Signal Transduction Pathways in Ageing. In: Harris, J. R. and Korolchuk, V. I. eds. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Springer, pp. 323-350.

Slack C (2017). Ras signalling in aging and metabolic regulation. Nutrition and Healthy Aging 4: 195-205.

Castillo-Quan JI, Li Li, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L (2016). Lithium Promotes Longevity through GSK3/NRF2Dependent Hormesis. Cell Reports 15: 638-650.

Slack C, Alic N and Partridge L (2015). Could cancer drugs provide ammunition against aging? Cell Cycle 15: 153-155.

Slack C, Alic N, Foley A, Hoddinott M, Cabecinha M, Partidge L (2015). The Ras-Erk-ETS pathway is a drug target for longevity. Cell 62:72-83.

Alic N, Tullet J, Niccoli T, Broughton S, Hoddinott M, Slack C, Gems D and Partridge L (2014). Cellnonautonomous effects of dFOXO/DAF-16 in ageing. Cell Reports 6:608-16.

Slack C and Partridge L (2013). Genes, pathways and metabolism in ageing. Drug Discovery Today: Disease Models 10: e87-e93.

Slack C, Foley A, Partridge L (2012). Activation of AMPK by metformin is insufficient to extend lifespan in Drosophila. PLoS One 7:e47699.

Alic N, Hoddinott MP, Foley A, Slack C, Piper MD, Partridge L (2012). Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. PLoS One 7: e45367.

Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cochemé HM, Schuster EF, Thornton JM, Partridge L (2011). Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Molecular Systems Biology 7: 502.

Slack C, Giannakou ME, Foley A, Goss M, Partridge L (2011). dFOXO-independent effects of reduced insulin-like signalling in Drosophila. Aging Cell 10: 735-748.

Wigby S, Slack C, Gronke S, Martinez P, Calboli FCF, Chapman T, Partridge L (2011) Insulin signalling regulates remating in female Drosophila. Proceedings Biological Sciences 278: 424-431.

Slack C, Werz C, Wieser D, Alic N, Foley A, Stocker H, Withers DJ, Thornton JM, Hafen E, Partridge L (2010). Regulation of lifespan, metabolism and stress responses by the Drosophila SH2B protein, Lnk. PLoS Genetics 6(3):e1000881.

Broughton S, Slack C, Alic N, Metaxakis A, Bass TM, Driege Y, Partridge L (2010). DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell. 9: 336 - 346.

Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L (2010). Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metabolism 11:35-46.

Broughton S, Alic N, Slack C, Bass T, Ikeya T, Vinti G, Tommasi AM, Driege Y, Hafen E, Partridge L (2008). Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS One 3:e3721.

Slack C, Overton PM, Tuxworth RI, Chia W (2007). Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosome. Development 134:3781-7. (Corresponding author).

Slack C, Somers WG, Sousa-Nunes R, Chia W, Overton PM (2006). A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions. BMC Genetics 7: 33.

Richardson MC, Slack C, Stewart IJ (2000). Rearrangement of extracellular matrix during cluster formation by human luteinising granulosa cells in culture. Journal of Anatomy 196: 243-248.